Focus on improving our planet.
Let's collaborate for sustainability &
digitalization.

Open innovation Platform for sustainability.
Find the right opportuinty and grow up your
innovation ecosystem.

Sign in/up

Search an
opportunity

Do you want to be part of innovative a sustainable project? Search for your opportunity and make your contribution to for the sustainable growth of the economy and the planet.

Tech collaborations
Joint Ventures
Licensing
Subcontracting
Investment

Express interest
Artificial interferons for treatment of infections
created · Updated
Deadline: Nov 22, 2021
Received 0 expressions of interest

Summary

A German university offers chimeric mutants of interferon alpha 2 and other interferon alpha subtypes with improved antiviral activity for treatment of chronic or acute viral infections, bacterial or parasitic infections or tumour therapy. These interferons are characterized by a high biocompatibility. The university offers license agreements

Description

Interferons are a family of proteins that were originally named for their ability to interfere with viral replication and propagation. To date, it is known that interferons are also involved in combating bacterial and parasitic infections, inhibit cell division, and promote or impede the differentiation of cells. Of the known IFN alpha (IFNa) subtypes, only IFNa2 has been extensively studied for its pharmaceutical potential. IFNa2 is therapeutically used for treatment of chronic infection with Hepatitis B Virus (HBV), but leads to a sustained virus control in less than 20% of the treated patients. In chronic human immunodeficiency Virus (HIV) infection its efficacy is even lower, with the results that it has been clinically used in only very few studies.

Researchers of a German university have discovered that IFNa14 is more efficient for the treatment of HBV and HIV infections. Whereas the most potent IFNa subtype against influenza virus is IFNa16. These findings were not only generated in vitro, but also in humanized mouse models and human organoid cultures. Based on these and earlier findings regarding the different antiviral activities of IFNa subtypes, the researchers designed chimeric mutants of the known IFNa2 and IFNa6/IFNa14/IFNa16 proteins that use the IFNa2 backbone, which is clinically well-established, with a variety of point mutations derived from the IFNa6/IFNa14/IFNa16 amino acid sequences that show significantly higher antiviral activity than IFNa2 (see figure).

Several mutants have been generated for the treatment of chronic (e.g. HBV, HDV, HIV) or acute (e.g. Influenza, Zika, Corona) viral infections, bacterial or parasitic infections or for adjunct tumor therapy (e.g. renal-cell carcinomas, cutaneous melanoma, hairy-cell leukemia, leukemia, melanomas).

The university offers license agreements to pharmaceutical industry.

Advantages & innovations

• Higher antiviral efficacy than conventional IFN alpha 2 therapy • High biocompatibility • IFNα2 as drug backbone is clinically well-established • Applies to a broad range of viruses

Stage of development

Under development/lab tested

Partner sought

The invention is available for licensing and further development together with the researchers of the university. Potential partners come from the pharmaceutical industry.

Create an
opportunity

Show your project-opportunity to generate interest of potential partners or collaborators. Companies, freelancers, or research centers can meet in Nir-vana and become perfect team together!

Latest Opportunities

EIT Food Public Engagement Proof of Concepts Call for Proposals 2023,...

published
Deadline: Aug 15, 2024
Project full name: EIT Food Public Engagement Proof of Concepts Call for Proposals 2023, 2024, 2025
Project acronym: EIT Food PE PoC Call 2023, 2024, 2025
Grant agreement number: N/A
Total EU funding available: €360 000 per submission window (total for 3 rounds: €1 380 000)
By the date of the Calls’ launches a webpage will be activated at eitfood.eu/projects/public-engagement-proof-of-concepts-call

Join and create
your ecosystem

Meet and connect with experts from around the world. Generate your innovative ecosystem and interact with them thanks to the different functionalities of Nir-vana: exchange spaces, lists of opportunities, expression of interest

Patricia Arcos
Francesc Saldaña
Build your project with
the best professionals
in the sector
Latest Opportunities

    EIT Food Public Engagement Proof of Concepts Call for Proposals 2023,...

    published
    Deadline: Aug 15, 2024
    Project full name: EIT Food Public Engagement Proof of Concepts Call for Proposals 2023, 2024, 2025
    Project acronym: EIT Food PE PoC Call 2023, 2024, 2025
    Grant agreement number: N/A
    Total EU funding available: €360 000 per submission window (total for 3 rounds: €1 380 000)
    By the date of the Calls’ launches a webpage will be activated at eitfood.eu/projects/public-engagement-proof-of-concepts-call
    Swedish SME in the hygiene sector produces washable re-usable absorbent underwear helping people with little leaks such as incontinence (urine escape due to bladder weakness) or other forms of leakage during periods or pregnancy. Compared to disposable products they are environmentally sustainable, less costly, providing a sense of normalisation and comfort for users. The SME is looking for sales agents, retailers, distributors interested in entering business collaboration agreements
    Company based in Sweden, is a pioneering force in digital cleaning training, specializing in e-learning for cleaners, supervisors, and clients. With a proven track record since 1994 and a recent foray into international markets, companyseeks strategic partnerships in Europe.
    Spanish company manufacturing vinegars, lemon juice, food dressings, balsamic creams and other related products in different types of containers and different formats and weights, is looking for wholesaler or distributor. Preferred channels: supermarkets, large distribution, convenience stores, hospitality services (hotels, restaurants and catering), gourmet shops and others.

The most relevant open & connected
network for sustainable business development.

Join now!

Sustainable
projects

Nir-vana wants to be the first open innovation platform focus on sustainability.

According to the EU Action Plan there is a huge need of change to a more sustainable future and to collaborate and assure to achieve the SDG.

Network
& experts

Nir-vana is the only platform integrating seamless "search and find" to the next stage of collaborating.

Get connected with experts and companies for partnering. Find trusted innovation advisors, certified by Enterprise Europe Network and build up your team of partners, companies and experts you need for your innovation.

Find public funding &
private investors

Discover potential funding opportunities for your innovation. On nir-vana you have access to national and EU funding programmes, public funding and private investors.

Get connected to consultants and advisors specialised on funding and grant preparation.