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Method for rapid detection of Candida auris and diagnosis of...
created · Updated
Deadline: Jul 28, 2021
Received 0 expressions of interest

Summary

A Spanish biomedical research networking center has developed an innovative biosensor for the detection of DNA of Candida auris and/or diagnosis of infection caused by this new and multi-resistant species of a pathogenic fungus. they are looking to establish license, research cooperation, or joint venture agreements.

Description

This research networking center gathers some of the main Spanish research groups in biomedicine, located in more than 100 institutions as universities, hospitals and technological centers distributed around the country.
Candida auris (C. auris) is an emerging species highly resistant to currently available antifungal drugs that can cause fungemia and deep infections associated with high mortality, especially in patients admitted to medical intensive care unit (MICU) or surgical intensive care unit (SICU). The first reported isolation of C. auris was a species in Japan with external otitis in 2009. Since then, disseminated infections and candidemia caused by this species have been described in several countries, including India, South Korea, South Africa, United Kingdom, United States, Colombia, Venezuela, Kuwait, and, recently, Spain, causing a worldwide health problem.
The identification of C. auris in biological samples represents a significant diagnostic challenge due to the difficulty in correctly identifying it with the biochemical techniques commonly used in microbiology laboratories. Many of these techniques mistakenly identify it as Candida haemulonii, Candida famata, Saccharomyces cerevisiae or Rhodotorula glutinis. Molecular methods outside the reach of most clinical laboratories are required to correctly identify a C. auris isolate, such as amplification and sequencing of ITS (Internal Transcribed Spacer) or MALDI-TOF MS (Matrix Assited Laser Desorption Ionization Time of Flight Mass Spectrometry).
Due to these important methodological difficulties for the correct identification of C. auris, which also require a lot of time, and specialized personnel and equipment, it is very likely that the infections caused by this species have been underdiagnosed or misidentified in recent years. This makes the development of new fast and reliable diagnostic methods necessary.
The present invention describes a biosensor for the detection of DNA of C. auris and/or diagnosis of infection caused by this new and multi-resistant species of pathogenic fungus that solves the problems of the devices and methods of the state of the art.
This innovative technology allows fast and easy detection of C. auris with a high level of sensitivity and selectivity. Based on this biosensor, a detection method and a method of diagnosing diseases caused by said pathogenic fungus have also been developed.
Potential industrial partners, either Biotech or Medtech, are sought in order to enter into R&D collaboration (further development of the medical device) until clinical proof-of-concept and ultimately the commercialization of the product (license agreement); or research organization for further development of the device, in order to collaborate in innovation projects (clinical proof-of-concept). Besides, an investor for financial support for setting-up of a spin-off company is sought under a joint venture agreement.

Advantages & innovations

The biosensor is based on a porous material that comprises an indicator and single-stranded DNA oligonucleotides that specifically recognize a region of Candida auris DNA. When the Candida auris is present in the medium, the oligonucleotides recognize that DNA region of the fungus, bind to it, and the release of an indicator by which the fungus can be detected occurs. This method allows fast and easy detection of C. auris with a high level of sensitivity and selectivity. No specialized personnel are required, this is a simple method of detection by direct visual observation of the medium. Detection and / or quantification of diagnosis are carried out in one hour, reducing the time of tests used routinely. The in vitro diagnostic method developed is suitable for detecting and/or quantifying C. auris in samples from subjects infected with the fungus. Subjects are human, but can also be animals, preferably mammals. Clinical samples suitable for the use of the invention are body fluids, such as blood, serum, sputum, pleural fluid, peritoneal fluid, synovial fluid, and cerebrospinal fluid. A Kit has been prepared to comprise biosensor, buffers, delivery vehicles, material supports, positive and/or negative control components, and use instructions.

Stage of development

Under development/lab tested

Partner sought

Any of the next types of collaborations are sought: • Industry for further development of the device (clinical proof-of-concept), in order to collaborate in innovation projects under research cooperation. • Industry willing to licensing-in the technology (product). • Research organization for further development of the device, in order to collaborate in innovation projects (clinical proof-of-concept) under research cooperation. • Investor for financial support for setting-up of a spin-off company via joint venture.

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